Author ORCID Identifier

https://orcid.org/0000-0002-8868-6611: PeiHan Xu

Standing

Graduate (Masters)

Type of Proposal

Oral Research Presentation

Faculty Sponsor

Dr. John F. Trant

Abstract/Description of Original Work

Cyanine dyes are fluorescent compounds commonly used in biosensors because of their great compatibility in vivo and high extinction coefficient, which has made it the perfect choice for our previous studies investigations into prostate cancer. Although cyanine dyes are commercially available, they are very expensive with only few suppliers and problematic synthesis. To facilitate our cancer research projects, we have sought to develop improved synthetic routes to these useful compounds.

In this presentation I will describe our work towards the improved synthesis of some of the cyanine dyes, Cy3 and Cy5. The difficulties (and successes) of the synthesis will be analysed and extension of these methods to other members of the family will be discussed.

Availability

31th,1st

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Which colour do you want for your cells, pink or blue? -Improving the synthesis of cyanine dyes

Cyanine dyes are fluorescent compounds commonly used in biosensors because of their great compatibility in vivo and high extinction coefficient, which has made it the perfect choice for our previous studies investigations into prostate cancer. Although cyanine dyes are commercially available, they are very expensive with only few suppliers and problematic synthesis. To facilitate our cancer research projects, we have sought to develop improved synthetic routes to these useful compounds.

In this presentation I will describe our work towards the improved synthesis of some of the cyanine dyes, Cy3 and Cy5. The difficulties (and successes) of the synthesis will be analysed and extension of these methods to other members of the family will be discussed.