Ag(I) Therapeutic Coordination Polymers as Controlled Release Materials
Standing
Undergraduate
Type of Proposal
Oral Research Presentation
Challenges Theme
Open Challenge
Faculty Sponsor
Nick Vukotic
Proposal
Many pharmaceuticals suffer from poor release kinetics, which limits their overall therapeutic potential. A potential solution is to use Controlled Release Materials (CRMs) to control the rate of drug release. Recently, coordination polymers have emerged as an attractive platform for controlled-release drug materials. Herein, we report two AgI therapeutic coordination polymers (TCPs), [{Ag2(L)(Dic)2]∞ and [{Ag2(L)2(Dic)2]∞ , consisting of the Non-Steroidal Anti-Inflammatory Drug (NSAID) Diclofenac (Dic), and a biocompatible organic linker derived from niacin, 3-3’-(1,4-butanediyl) di-3-pyridinecarboxylate (L) of varying stoichiometric ratios for the application of controlled release of diclofenac. Our materials demonstrated reproducible and high drug loadings of 53% and 42%, respectively, and are easily scalable. Single crystals of our TCPs were grown under ambient conditions and were characterized using single-crystal X-ray diffraction, whereas the bulk material was characterized using powder X-ray diffraction, elemental analysis, and thermal gravimetric analysis. Dissolution studies under simulated physiological conditions comparing the drug release profiles and intrinsic dissolution rates between the two AgI TCPs will be investigated. The differences in the packing between the two coordination polymers and its effect on the dissolution rate will also be presented.
Grand Challenges
Viable, Healthy and Safe Communities
Ag(I) Therapeutic Coordination Polymers as Controlled Release Materials
Many pharmaceuticals suffer from poor release kinetics, which limits their overall therapeutic potential. A potential solution is to use Controlled Release Materials (CRMs) to control the rate of drug release. Recently, coordination polymers have emerged as an attractive platform for controlled-release drug materials. Herein, we report two AgI therapeutic coordination polymers (TCPs), [{Ag2(L)(Dic)2]∞ and [{Ag2(L)2(Dic)2]∞ , consisting of the Non-Steroidal Anti-Inflammatory Drug (NSAID) Diclofenac (Dic), and a biocompatible organic linker derived from niacin, 3-3’-(1,4-butanediyl) di-3-pyridinecarboxylate (L) of varying stoichiometric ratios for the application of controlled release of diclofenac. Our materials demonstrated reproducible and high drug loadings of 53% and 42%, respectively, and are easily scalable. Single crystals of our TCPs were grown under ambient conditions and were characterized using single-crystal X-ray diffraction, whereas the bulk material was characterized using powder X-ray diffraction, elemental analysis, and thermal gravimetric analysis. Dissolution studies under simulated physiological conditions comparing the drug release profiles and intrinsic dissolution rates between the two AgI TCPs will be investigated. The differences in the packing between the two coordination polymers and its effect on the dissolution rate will also be presented.