“The Synergistic Effects of Rosemary, Long Pepper, and Synthite Tea Extracts with Chemotherapy on Reducing Toxicity to Non-Cancerous Cells in HCT-116 Colon Cancer Cell Line'
Standing
Undergraduate
Type of Proposal
Oral Research Presentation
Challenges Theme
Open Challenge
Faculty Sponsor
Dr.Siyaram Pandey
Proposal
Chemotherapy is the primary treatment for colon cancer but it can cause adverse effects in patients and can compromise their quality of life. Natural extracts have shown promising results in selectively targeting cancer cells, but their efficacy in combination with chemotherapy remains unknown. The purpose of this study is to evaluate the potential of combining Rosemary, Long Pepper, and Synthite Tea extracts with chemotherapy to selectively target cancer cells in the HCT-116 colon cancer cell lines. Various concentrations of these extracts were tested, and selective apoptosis induction was assessed using AVPI, TRM, and H2DCFDA assays. Further experiments will be conducted to demonstrate that these extracts are selective towards cancer cells and do not cause toxicity to noncancerous cells when combined with chemotherapy. The results suggest that these extracts could offer a healthier and more effective approach in treating colon cancer.
Grand Challenges
Viable, Healthy and Safe Communities
“The Synergistic Effects of Rosemary, Long Pepper, and Synthite Tea Extracts with Chemotherapy on Reducing Toxicity to Non-Cancerous Cells in HCT-116 Colon Cancer Cell Line'
Chemotherapy is the primary treatment for colon cancer but it can cause adverse effects in patients and can compromise their quality of life. Natural extracts have shown promising results in selectively targeting cancer cells, but their efficacy in combination with chemotherapy remains unknown. The purpose of this study is to evaluate the potential of combining Rosemary, Long Pepper, and Synthite Tea extracts with chemotherapy to selectively target cancer cells in the HCT-116 colon cancer cell lines. Various concentrations of these extracts were tested, and selective apoptosis induction was assessed using AVPI, TRM, and H2DCFDA assays. Further experiments will be conducted to demonstrate that these extracts are selective towards cancer cells and do not cause toxicity to noncancerous cells when combined with chemotherapy. The results suggest that these extracts could offer a healthier and more effective approach in treating colon cancer.