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Chemistry and Biochemistry Theses and Dissertations

Theses/Dissertations from 2024 2024

Geoforensic tracing of contaminants and emissions: Monitoring watersheds, petroleum, and helium operations, Meagan Beaton

Allosteric regulation of the deubiquitinase USP8 and applications of ubiquitin variant tool molecules., CODY CABA

Oxidative Addition Chemistry of bis(4,5-dimethoxybenzo)-1,2,5,6-tetrathiocin with Bidentate Phosphines and Cyclopentadienyl Metal Carbonyls, Mary El Rayes

Investigating Phosphorylation of the Myotubularin Family Members MTMR2 and MTMR5 Using High Resolution Mass Spectrometry, Kaitlyn Susan Maureen Hand

Medicinal Mushrooms: The Extraction and Analysis of Bioactive Compounds from Hericium erinaceus and Ganoderma lucidum Mushrooms., Jhanielle Amanda-Kaye James

Accessibility & Efficiency: Insights into the impact of dedicated computational tools on Biophysical Research, Aislyn Ann Laurent

Computational Studies on Enzyme-Related Chemistry, Basel A. Mansour

Improving Extraction Procedure and a Comparative Analysis of Bioactive Molecules from Ganoderma Lucidum, Hericium Erinaceus and Cordyceps Mushrooms, Mohaddeseh Mansouri

Sustainability by Design: Carbohydrate Side Chain Engineering for Greener Semiconducting Polymers in Organic Electronics, Madison Mooney

Unconventional Strategies for Crafting Cyclic Compounds with a Twist: Peptides, Cavitands, and Crown Ethers, Sanaz Nadimi

Investigation of the anti-cancer activity of multiple novel proprietary, and previously characterized natural extracts in multiple colorectal cancer models: Efficacy in targeting human colorectal cancer cells, and analysis and toxicology of in-vivo response, Benjamin Scaria

New Synthetic Strategies and Applications Using Nicholas Reaction Chemistry, Brent Andrew St.Onge

Dynamic Metal-Ligand Interactions in Semiconducting π-Conjugated Materials, Peter Blake Joseph St Onge

ALVEOLI-IN-A-DISH: 3D-BIOPRINTED HUMAN LUNG TISSUE MODEL FOR INHALATION TOXICITY, Jessica Katherine Szawara

Identifying Soil Gas Migration Issues Using Complementary Geochemistry and Microbial Bioindicators, Nadia Sultana Tarakki

HepatoToxicity-in-a-Dish: Human Microphysiological System for Liver Injury, Lucas Joseph Aaron Marie Vajko Siddall

Theses/Dissertations from 2023 2023

Progress towards stimuli-responsive properties of self-immolative pseudopeptides, Mana Dashti

Novel geochemical approaches to manage greenhouse gas emissions from thermal oil operations, Karlynne Dominato

Functional Characterization of HoDI, a DEAD-box RNA Helicase in Toxoplasma gondii, using RNA-Protein Tethering Assay, Ronaldo Eid

Mechanistic Studies of Inert Bond Functionalization by Mono and Polynuclear Ni Complexes, Jun Yang Liu

Exploring the Impact of Src-Directed Phosphorylation on hYVH1’s Intracellular Function, Griffin Lotze

Investigating Structural Determinants of the hYVH1-Hsp70 Interaction Using High Resolution Mass Spectrometry, Adrian A. Luiso

Cancers, Cannabinoids, COVID and Autoimmune Disorders: Investigating Biological Activity by Computational Chemistry, Daniel Meister

Biophysical Insights into Peptide and Alcohol Perturbations on Biomimetic Membranes, Michael Hai Nguen

Supramolecular and Covalent Crosslinking of Organic Semiconductors, Audithya Narasimha Nyaychavadi

Optimization of equilibrated headspace technique for compositional and isotopic analysis of dissolved gases, Michelle Tsuey-Yee Quan

Exploring Paper as a Substrate for Printed Electronics, Lauren Jessica Renaud

A tale of two mechanisms: Is the p53 modulator COTI-2 a zinc chaperone instead?, Irem Simsek

Developing New Strategies Towards the Fabrication of Flexible, Organic Electronics, Daniella Skaf

Theses/Dissertations from 2022 2022

35CI Solid-State NMR Characterization of Polymorphs and Cocrystals of Xylazine HCI, Louae M. Abdulla

Thiophene Substituted 1,3,5-Triazines as Building Blocks for Liquid Crystals, Mojtaba Samiei Alalani

Evaluation of field-level screening, sampling, storage, and laboratory analysis of hydrogen sulfide and reduced sulfur species in SAGD operations, Kaylee Colene Anagnostopoulos

Diketopyrrolopyrrole Derivatives for Single Material Solar Cells, Adam M. Cassar

Structure and Mechanics of Biomembrane Mimics in the Presence of Vitamin E, Mitchell DiPasquale

The Design and Testing of Fluorescence-Based Sensors for Phosphate and Phosphonate, Sara Hassanzadehroknabadi

Advanced Substrates for Wearable and Printed Electronics, Sara Mechael

Studies of Layered Elastomeric Substrates and Shellac Films for Stretchable and Printed Electronics, Calum Noade

Dynamic Interactions in Semiconducting Polymers; New Materials for Soft Electronics with Biomimetic Properties, Michael Udunyi Ocheje

Development and Characterization of a Platform to Characterize Putative Inhibitors Targeting the SARS CoV-2 RNA-Dependent RNA Polymerase, Fasih Rehman

RNP Granules in Toxoplasma gondii: Function and Formation, Scott Roscoe

Development of novel therapies targeting biochemical mechanisms to halt progression of Alzheimer’s and Parkinson’s Disease, Caleb Vegh

Elucidating Mechanisms for S-Nitrosoglutathione Reductase Activity and Control in Plants Using O-Aminobenzoyl-S-Nitrosoglutathione and a Novel Photo-Sensitive Probe, Leslie Ventimiglia

The Life and Death of Organic Electronics: Controlling Degradation and Regeneration through Molecular Materials Design, Susanna Vu

A Comparison of the Oxidative Addition Chemistry of Tetrathiocins to p- and d- Block Elements, Lara Watanabe

Theses/Dissertations from 2021 2021

Regulation of the Ribosome Biogenesis Factor hYVH1 by Src-mediated Phosphorylation, Ashley Anne DaDalt

HLA Blockers for potentially treating Rheumatoid arthritis, Samaneh Mehri

Computational Enzymology on Sulfur-Containing Enzymes: From Method to Application, Paul Meister

Computational Enzymology on Sulfur-Containing Enzymes: From Method to Application, Paul Meister

The Valorization of Agricultural by Products for the Removal of Inorganic Phosphate from Water, David Ure

Examining Biomolecular Interactions and Their Significance in Toxoplasma gondii Survival and Infection, Grace Wen

Soybean Peroxidase Catalyzed Oligomerization of Acetaminophen and Selected Parabens for Wastewater Treatment, Baturh Yarkwan

Theses/Dissertations from 2020 2020

Methods Development for the Fluorescent Determination of Inorganic Phosphate and Phospho-Proteins, Angela Awada

Nonlinear Phenomena during the Electrochemical Oxidation of Sulfur Compounds, Michelle Dao

Gas Migration Testing at Abandoned Well Sites in Western Canada, Kelsey Lauren Friesen

Characterization of Novel Cellular Systems Using Labelfree Quantitative Proteomics, Robert Gombar

Diketopyrrolopyrrole-Based Conjugated Polymer Nanoparticles Toward New Theranostics for Glioblastoma Multiforme, Gage Mason

Development of A Robust, Soft and Flexible Selfhealing Polymer Based on Dynamic Coordinate Metallig and Bonds, Julia Pignanelli

Mechanism Determination of the Effects of Pancratistatin on Model Mitochondrial Membranes, Brett William Rickeard

Investigation of proteins and their modifications using high-resolution mass spectrometry, Justin Roberto

Progress towards the Synthesis of Carbohydrate-Based Biomedical and Material-Science Relevant Molecules, Seyed Iraj Sadraei

Reformulation of Catalent's Vitamin A/E Supplement, Nicholas Anthony Salvati

New Designs for Wearable Technologies: Stretchable e-Textiles and e-Skin, Yunyun Wu

Mood-Beads-On-A-String: Development of benzimidazolium based axles with pseudodegenerate recognition sites and highly sensitive optical response, Xiao Yu

Theses/Dissertations from 2019 2019

Metal-Mediated Vinylogous Nazarov Cyclization Reaction, Somaiah Khalid Almubayedh

Fundamental Chemistry Involving Carbon-Donor-Stabilized Phosphorus(I) and Arsenic(I) Salts, Justin Frank Binder

Synthesis, Reactivity and Computational Studies of 1,4-Dialkyl-1,2,4-Triazol-5-ylidene Phosphorus(I) Cations, Fawzia Omar Elnajjar

Investigating Natural Antisense Transcripts in Toxoplasma gondii, Ambreen Fahim

Composites of Poly(dimethylsiloxane) and Silica Nanoparticles as an Approach to Manipulating the Conductivity of Stretchable Gold Films, Brittany Ives

Crystalline Materials Incorporating Rotaxanes and Porphyrins, Pablo Alen Martinez Bulit

Oxidative Polymerization of Heterocyclic Aromatics Using Soybean Peroxidase for Treatment of Wastewater, Neda Mashhadi

Anticancer Activity of Natural Health Products (Dandelion Root, Lemongrass, and Hibiscus Extracts); A Study of Efficacy, Interaction, and Mechanism of Action, Christopher Vu Nguyen

Computational Insights into Bio-relevant Sulfur Chemistry, Sahar Nikoo

Structure-function relationship in S-nitrosoglutathione reductase and the development of fluorogenic pseudo-substrates, Nneamaka Chinwendu Onukwue

Design and Preparation of Stretchable Semiconductors Through Polymer Blending, Mariia Selivanova

Exploring the roles of the CXXC motifs in Cystathionine γ-Lyase, Scott Smith

Inclusion Chemistry and Crystal Engineering of Dithiadiazolyl and Diselenadiazolyl Radicals, Nadia Theresa Stephaniuk

Synthesis, Characterization, and Reactivity of Chelating Ligand Complexes of Group 13-15 Elements, Ala'aeddeen Swidan

Mesomorphic Dyes based on Conformationally Flexible 1,3,5-Triazines, Hi Taing

Phosphine Supported Mono-and Polynuclear Ni Complexes for Inert Bond Activation: Mechanisms and Isolation of Reactive Intermediates, Sha Zhu

Theses/Dissertations from 2018 2018

Investigation of the RNA-interference pathway of Toxoplasma gondii, Farzana Afrin

Computational Insights into Sulphur-Crosslinking Enzymatic Mechanisms, Taqred Hussain Alnakhli

Preparation and characterization of radical-coated nanoparticles, Aisha Abdulwahab Alsaleh

Development and Integration of Stretchable Electronic Components into Light-Emitting Devices.pdf, Yiting Chen

Studies on Nitric Oxide Generation and its Enzymatic Degradation, Kathleen Fontana

A Potential Role for Sortilin in Lp(a) and Apo(a) Metabolism, Matthew Gemin

STRUCTURAL STUDIES AND CRYSTAL ENGINEERING OF DITHIADIAZOLYL RADICALS AND THEIR METAL COMPLEXES, Mitchell Anthony Nascimento

Multinuclear Solid-State NMR Investigation of Structure, Dynamics, and Formation of Porous Materials, Christopher Andrew O'Keefe

Towards Putting the ‘P’ in Perovskite: Exploring the Reactivity of Phosphonium Salts with Group 14 Halides, Emily Helen Omahen

Functionalization of ε-Carbonyl Cation Equivalents Facilitated by Lewis Acid Catalysts, Page Penner

Cymbopogon citratus and Camellia sinensis extracts selectively induce apoptosis in cancer cells and reduce growth of lymphoma xenografts in vivo, Cory Philion

New derivatives of 1,2,4-benzothiadiazines and their coordination chemistry, Konstantina Pringouri

Rotaxane Incorporated Coordination Cages, Peter Alexander Rowsell

Green and Low Cost Mechanochemical Synthesis of 3,3’,5,5’-Azobenzene Tetracarboxylic Acid, Sarah Salloum

The Effect of Single Nucleotide Polymorphisms in Apolipoprotein(a) KIV Types 6-9 on Lipoprotein(a) Particle Assembly and Apolipoprotein(a) Secretion In Vitro, Sera Sayegh

New Polyether Complexes of Germanium(II) and Tin(II): Synthesis, Structural Characterization and Reactivity, Alina Maria Secara

Cooperative Bond Activation by an Electron-Deficient Pentanuclear Nickel Hydride Cluster, Manar Matti Shoshani

Reticular Synthesis of Metal-Organic Rotaxane Frameworks, Alexander Joseph Stirk

Theses/Dissertations from 2017 2017

Computational Insights into the High-Fidelily Catalysis of Aminoacyl-tRNA Synthetases, Mohamed M. Aboelnga

Expanding the Oxidative Addition Route for the Rational Design of Multi-Metallic Dithiolene Complexes, Zeinab Sadiq Ahmed

Benzimidazole Based Anion Transporters; Incorporation of [2]Rotaxanes into Membrane Transport Studies, Emilyn Anderi